When Should Children with HIV Infection Be Started on Antiretroviral Therapy
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چکیده
منابع مشابه
When Should Children with HIV Infection Be Started on Antiretroviral Therapy?
BACKGROUND TO THE DEBATE The advent of highly active antiretroviral therapy (HAART) dramatically improved the prognosis for both adults and children infected with HIV who had access to treatment. However, the optimal timing for initiating treatment remains controversial, particularly in children. This debate lays out the case for deferred treatment against the case for early initiation of HAART...
متن کاملWhen should antiretroviral therapy be started in HIV-positive persons?
Recommendations for the initiation of combination antiretroviral therapy in HIV-positive individuals are largely based on data from observational studies. Whilst all guidelines recommend immediate treatment in individuals with a CD4 count of less than 350 cells/mm(3), guidelines vary in their recommendations for treatment at higher CD4 counts. Several large cohort studies have published finding...
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US treatment guidelines now recommend antiretroviral therapy (ART) for all persons infected with human immunodeficiency virus (HIV), regardless of CD4 count, both for the benefit of infected individuals and to prevent HIV transmission. In an effort to meet the critical goal of treating all HIV-infected persons worldwide, there is movement toward extrapolating these guidelines and the data suppo...
متن کاملShould antiretroviral therapy for HIV infection be tailored for intracerebral penetration?
The continuous replication of HIV-1 in the central nervous system, in particular the brain, and its potential long-term deleterious effect is the focus of this review. Cognitive deficits are observed in a significant percentage of HIV-1-infected patients. That may occur despite successful peripheral suppression of the HIV-1 replication. Compartmentalisation of HIV-1 in the brain, genetic mutati...
متن کاملWhen should we treat children with HIV?
Romanelli et al. have reviewed the evolution of antiretroviral (ARV) therapy implemented between January 1998 and December 2001 at Universidade Federal de Minas Gerais (UFMG) and concluded that triple drug regimens were more effective than dual drug therapy.1 Their conclusion mirrors, in part, US pediatric guidelines for antiretroviral therapy in HIVinfected children. Initially developed in 199...
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ژورنال
عنوان ژورنال: PLoS Medicine
سال: 2008
ISSN: 1549-1676
DOI: 10.1371/journal.pmed.0050073